To connect to a MySQL database from Django or a python script you have to install MySQLdb. The installation of the package on MacOSX is not straightforward, so here is a small howto.

• Download and unpack the MySQLdb package
• Edit the setup-posix.py file, and change the line below:

  mysql_config.path = "mysql_config"
  to
  mysql_config.path = "/usr/local/mysql/bin/mysql_config"
  

  Note: you have to specify the path to your mysql_config unless you have installed mysql.com package for mac

• Build

   python setu.py clean
   python setup.py build
   sudo python setup.py install
  

  If you get this compile error

  /usr/include/sys/types.h:92: error: duplicate ‘unsigned’
  /usr/include/sys/types.h:92: error: two or more data types in declaration specifiers
  

  edit the _mysql.c file and comment this line

  #define uint unsigned int